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|Pronunciation||/ d ɪ ˈ dʒ ɒ k s ɪ n /, with a soft gee |
|Trade names||Lanoxin, others|
|Pregnancy category||AU: A US: C (Risk not ruled out)|
|Routes of administration||by mouth, intravenous|
|ATC code||C01AA05 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only|
|Bioavailability||60 to 80% (by mouth)|
|Elimination half-life||36 to 48 hours (normal kidney function) 3.5 to 5 days (impaired kidney function)|
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This increase of cyclic AMP leads to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation.
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American Board of Dermatology
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American Academy of Dermatology