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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
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Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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Discussion To our knowledge, this is the largest prospective series describing cases of severe ALI in patients exposed to therapeutic dosages of paracetamol that have ever been published. Those seven cases reported low alcohol consumption, except case number 1. A study in adults who developed liver failure induced by paracetamol overdoses showed a positive correlation between the serum concentration of acetaminophen-protein adducts and severity of hepatotoxicity, which can article source detected up to 12 days after ingestion

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